Isosorbide Dinitrate

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Cat No: 23990

Biochemicals - Ox Stress Reagents

Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.{36279} It induces vasodilation with IC50 values of 0.56 and 1.82 µM for isolated precontracted rabbit femoral vein and artery, respectivel...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,4:3,6-dianhydro-D-glucitol, 2,5-dinitrate

Correlated keywords:

6659-58-1 54650-95-2 Astridine Cardiket Cardio 10 Cardis Carvanil Carvasin Cedocard Claodical Corosorbide Corovliss Dignionitrat Dilatrate SR Diniket Dinitroisosorbide Dinitrosorbide Disorlon Duranitrat EV 151 EureCor Flindix Frandol Glentonin Harrical IBD ISDN Imtack Isdin Iso-Bid Mack Puren Isocard Isocore Isodinit Isoket retard 40 Isonate Isorbid Isordil Tembids Isosorbide 2,5-dinitrate Isostenase Isotrate Korodil langoran Laserdil Maycor Myorexon Nitorol Nitrofix Nitrol Nitrosorbid Nitrosorbide Nitrosorbonl Nosim Resoidan Rifloc Retard Rigedal Risordan SDM 25 40 Soni-Slo Sorbangil Sorbichew Sorbid SA Sorbide Dinitrate nitrate Sorbidilat Sorbidnitrate Sorbitrate Sorbonit Sorbopercuten Sorquad TYB 3215 Vascardin Vasorbate Vasotrate NSC80038

Product Overview:
Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.{36279} It induces vasodilation with IC50 values of 0.56 and 1.82 µM for isolated precontracted rabbit femoral vein and artery, respectively.{36280} Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model.{36282} It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range.{36281} Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.

Size	5 mg
Shipping	dry ice
CAS Number	87-33-2
Molecular Formula	C₆H₈N₂O₈
SMILES	[H][C@@]1([C@@H](O[N+]([O-])=O)CO2)[C@@]2([H])[C@H](O[N+]([O-])=O)CO1
Molecular Weight	236,1
Formulation	A solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.