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Droxinostat

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    Droxinostat
  • Droxinostat
Cat No: 23869
Biochemicals - Small Molecule Inhibitors
Cayman

Droxinostat is an inhibitor of histone deacetylase (HDAC) 3, 6, and 8 (IC50s = 16.9, 2.47, and 1.46 μM, respectively).{38617} It is selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 μM). Droxinostat increases histone H3 and H4 ace...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-(4-chloro-2-methylphenoxy)-N-hydroxy-butanamide
Correlated keywords:
  • NS41080 PPC1 OVCAR-3 U-937 SMMC7721 Hep-G2 HDAC-1 HDAC6 HDAC8 HDAC2 HDAC7 HDAC9 HDAC10 HT29 cFLIP
Product Overview:
Droxinostat is an inhibitor of histone deacetylase (HDAC) 3, 6, and 8 (IC50s = 16.9, 2.47, and 1.46 μM, respectively).{38617} It is selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 μM). Droxinostat increases histone H3 and H4 acetylation in PPC-1 prostate, OVCAR3 ovarian, U937 leukemia, HT-29 colon, and T47D breast cancer cells. It also inhibits proliferation and colony formation of SMMC-7721 and HepG2 hepatocellular carcinoma cell lines via activation of mitochondrial apoptosis and reduction of cellular FLICE-inhibitory protein (c-FLIP).{38618}
Size 1 mg
Shipping dry ice
CAS Number 99873-43-5
Molecular Formula C11H14ClNO3
SMILES ClC1=CC(C)=C(OCCCC(NO)=O)C=C1
Molecular Weight 243,7
Formulation A crystalline solid
Purity ≥98%
Custom Code 2903.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : Droxinostat There are 6 products.

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