Bisoprolol (hemifumarate)

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Cat No: 23827

Biochemicals - Receptor Pharmacology

Bisoprolol is a potent β-adrenergic receptor (β-AR) antagonist that is selective for β1-ARs over β2-ARs (Kis = 25 and 480 nM, respectively in S49 cells overexpressing the human receptors).{39505} It also selectively binds to β1-ARs over β2-ARs in huma...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol, (2E)-2-butenedioate (2:1)

Correlated keywords:

66722-44-9 105878-43-1 hemi-fumarate Concor Detensiel Emcor EMD33512 Emvoncor Eurtadal Isoten Maintate Monocor Soprol Zebeta ?AR ?1AR ?2AR SARS-CoV2 COVID corona-virus

Product Overview:
Bisoprolol is a potent β-adrenergic receptor (β-AR) antagonist that is selective for β1-ARs over β2-ARs (Kis = 25 and 480 nM, respectively in S49 cells overexpressing the human receptors).{39505} It also selectively binds to β1-ARs over β2-ARs in human myocardium (Kis = 75.8 and 991 nM, respectively).{39506} Bisoprolol binds to rat ventricular myocytes and heart membrane (Kis = 20 and 38.1 nM, respectively) and to rat β1-AR in salivary glands and β2-AR in reticulocytes (Kis = 24 and 1,945 nM, respectively).{39507,39508} In vivo, it inhibits increases in heart rate induced by isoproterenol (Item No. 15592) in guinea pigs.{39509} Bisoprolol (0.3 mg/kg) inhibits isoproterenol-induced increases in heart rate and myocardial contractility in conscious dogs. It also decreases blood pressure and heart rate in spontaneously hypertensive rats (SHRs) when chronically administered at a dose of 7.5 mg/kg twice per day over 19 weeks. Formulations containing bisoprolol have been used in the treatment of heart failure, angina pectoris, mild to moderate hypertension, and for secondary prevention of myocardial infarction.

Size	50 mg
Shipping	dry ice
CAS Number	104344-23-2
Molecular Formula	C₁₈H₃₁NO₄ • 1/2C₄H₄O₄
SMILES	OC(CNC(C)C)COC1=CC=C(COCCOC(C)C)C=C1.OC(/C=C/C(O)=O)=O
Molecular Weight	325,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.