Theophylline

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Theophylline

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Cat No: 23760

Biochemicals - Receptor Pharmacology

Theophylline is a methylxanthine alkaloid that is a competitive inhibitor of phosphodiesterase (PDE; Ki = 100 µM).{41252} It is also a non-selective antagonist of adenosine A receptors (Ki = 14 µM for A1 and A2).{41253} Theophylline induces relaxation...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione

Correlated keywords:

46157-00-0 56645-32-0 75448-53-2 111079-49-3 1024160-72-2 Accurbron Aerobin Aerolate Afonilm Apnecut Armophylline Asmax Austyn Bilordyl Brochoretard Bronkodyl Cetraphylline Chronophyllin Controfilina Diffumal Duraphyl Egifilin Elan Elixophyllin Elixophylline Etheophyl Euphylong GM-501 GM501 SpermMobil Insanovin LaBID Lanophyllin Lasma Liquophylline NSC2066 Nuelin Optiphyllin Parkophyllin Physpan Pseudotheophylline PulmiDur Pulmo-Timelets Quibron Respbid Respicur Slo-Phyllin Solosin Somophyllin Spophyllin Sustaire Talotren Telban Teocen Teonova Teotard Tesona Theobid Theochron Theoclear Theodel Theodrip Theodur Theofol Theograd Theolair Theon Theopek Theophyl Theophyllin Theoplus Theostat Theotard Theovent Throphylline Unicontin Unifyl Unilong Uniphyl Uniphyllin Xanthium dimethyl xanthine

Product Overview:
Theophylline is a methylxanthine alkaloid that is a competitive inhibitor of phosphodiesterase (PDE; Ki = 100 µM).{41252} It is also a non-selective antagonist of adenosine A receptors (Ki = 14 µM for A1 and A2).{41253} Theophylline induces relaxation of feline bronchiole smooth muscle precontracted with acetylcholine (EC40 = 117 µM; EC80 = 208 µM).{41254} Formulations containing theophylline have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Size	25 g
Shipping	wet ice
CAS Number	58-55-9
Molecular Formula	C₇H₈N₄O₂
SMILES	O=C1N(C)C(C(N=CN2)=C2N1C)=O
Molecular Weight	180,2
Formulation	A solid
Purity	≥98%
Custom Code	2924.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.