Mepenzolate (bromide)

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Cat No: 23717

Biochemicals - Receptor Pharmacology

Mepenzolate is an antagonist of muscarinic (M) acetylcholine receptors (Kis = 0.68 and 2.6 nM for human M2 and M3 receptors, respectively).{41272} It has antispasmodic activity in the gastrointestinal tract of anesthetized cats and dogs when administe...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monobromide

Correlated keywords:

88215-34-3 Trancolon NSC4358 JB340 JB-340 Cantil Cantilaque Cantilon Cantril Colibantil Colopiril Colum Delevil Gastropidil Glycophenylate N-Methyl-3-piperidyl benzilate methyl bromide IGF1 IL6 IL1? TNF? TGF?1

Product Overview:
Mepenzolate is an antagonist of muscarinic (M) acetylcholine receptors (Kis = 0.68 and 2.6 nM for human M2 and M3 receptors, respectively).{41272} It has antispasmodic activity in the gastrointestinal tract of anesthetized cats and dogs when administered at a dose of 0.5 mg/kg.{41273} Mepenzolate decreases airspace enlargement induced by elastase or cigarette smoke and reduces respiratory dysfunction in a mouse model of chronic obstructive pulmonary disease (COPD).{41274} It also reduces oxidative stress, decreases the expression of IL-1β, IL-6, and TNF-α, and increases the expression of TGF-β1, IGF-1, and VEGF in a diabetic wound healing mouse model.{41275}

Size	500 mg
Shipping	dry ice
CAS Number	76-90-4
Molecular Formula	C₂₁H₂₆NO₃ • Br
SMILES	C[N+]1(C)CCCC(OC(C(O)(C2=CC=CC=C2)C3=CC=CC=C3)=O)C1.[Br-]
Molecular Weight	420,3
Formulation	A solid
Purity	≥95%
Custom Code	2933.39
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.