6-Mercaptopurine (hydrate)

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Cat No: 23675

Biochemicals - Small Molecule Inhibitors

6-Mercaptopurine (6-MP) is an inhibitor of purine synthesis and interconversion.{36297} It is rapidly converted to 6-mercaptopurine ribonucleoside-5'-monophosphate, which inhibits phosphoribosyl pyrophosphate (PRPP) amidotransferase, the rate-limitin...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,2,3,9-tetrahydro-6H-purine-6-thione, monohydrate

Correlated keywords:

5759-99-9 5818-33-7 5818-60-0 39454-94-9 111079-50-6 50-44-2 thiohypoxanthine purimethol purinethol leupurin purine-6-thiol 6MP inosine monophosphate adenosine E0771 L-1210 ALL

Product Overview:
6-Mercaptopurine (6-MP) is an inhibitor of purine synthesis and interconversion.{36297} It is rapidly converted to 6-mercaptopurine ribonucleoside-5'-monophosphate, which inhibits phosphoribosyl pyrophosphate (PRPP) amidotransferase, the rate-limiting enzyme in purine synthesis. It also inhibits the conversion of IMP to adenylosuccinic acid and xanthylic acid and blocks AMP formation in vitro. 6-MP (30 mg/kg) inhibits growth of sarcoma 180, adenocarcinoma E 0771, and adenocarcinoma 755 tumors and reduces the size of leukemia L1210 subcutaneous growths in mice.{36298} It also decreases delayed-type hypersensitivity and thyroid inflammation in a guinea pig model of thyroiditis when administered pre- or post-disease onset.{36299} Formulations containing mercaptopurine have been used for maintenance therapy in patients with acute lymphoblastic leukemia.{36300}

Size	5 g
Shipping	dry ice
CAS Number	6112-76-1
Molecular Formula	C₅H₄N₄S • H₂O
SMILES	S=C1C2=C(NC=N2)N=CN1.O
Molecular Weight	170,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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