4-hydroxy Alternariol

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Cat No: 23636

Biochemicals - Small Molecule Inhibitors

4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol (Item No. 11306) formed through cytochrome P450 (CYP450) metabolism.{41226} It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control.{41...

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Territorial Availability: Available through Bertin Technologies only in France

                                            Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
                    

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Synonyms:

3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one

Correlated keywords:

4-Hydroxyalternariol 4OH-AOH 4OHAOH OHAOH KYSE 510 CYP II?DNA

Product Overview:
4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol (Item No. 11306) formed through cytochrome P450 (CYP450) metabolism.{41226} It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control.{41227} 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 µM under cell-free conditions.

Size	500 µg
Shipping	dry ice
CAS Number	959417-21-1
Molecular Formula	C₁₄H₁₀O₆
SMILES	CC1=C(C2=C(C(O3)=O)C(O)=CC(O)=C2)C3=C(O)C(O)=C1
Molecular Weight	274,2
Formulation	A solid
Purity	>95%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.