From €505.00 €429.25
CD48 is a glycoprotein and member of the signaling lymphocyte activation marker (SLAM) family that has diverse roles in innate and adaptive immunity.{59610} Alternative splicing of CD48 pre-mRNA produces one full-length isoform, CD48 long, and a short isoform, in humans.{59610} CD48 long is comprised of an extracellular N-terminal immunoglobulin (Ig) variable-like (IgV) domain that mediates heterophilic interactions, an Ig constant 2-like 2 (IgC2) domain, and a glycosylphosphatidylinositol (GPI) anchor that localizes CD48 to the cell membrane and facilitates intracellular signaling.{59610,59612} It is constitutively expressed on most human hematopoietic cells, including monocytes, neutrophils, and lymphocytes, and is localized to lipid rafts.{59610} CD48 is upregulated by inflammatory conditions, including cytokine stimulation, as well as bacterial or viral infection.{59610} It binds the co-stimulatory molecule CD2 on T cells and natural killer (NK) cells to promote immune synapse formation and T cell receptor signaling, as well as the bacterial lectin FimH, to enhance pathogen clearance. CD48 also binds CD244 on NK cells and certain subsets of T cells, regulating the activation and cytolytic function of these cells. CD48 levels are increased on plasma cells isolated from patients with multiple myeloma, and neutralization of CD48 with a monoclonal antibody reduces tumor growth in an OPM-2 mouse xenograft model.{59613} It is also increased on blood eosinophils in patients with atopic asthma.{59610} Cayman’s CD48 Long Isoform (human, recombinant) protein can be used for binding assay applications. This protein consists of 205 amino acids, has a calculated molecular weight of 23.8 kDa, and a predicted N-terminus of Gln27 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 40 kDa due to glycosylation.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Custom code | 3504.00 |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Purity | ≥95% |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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