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2-Trifluoromethyl-2'-methoxychalcone

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    2-<wbr/>Trifluoromethyl-<wbr/>2'-<wbr/>methoxychalcone
  • 2-<wbr/>Trifluoromethyl-<wbr/>2'-<wbr/>methoxychalcone
Cat No: 11881
Chemicals - Miscellaneous Chemicals
Cayman
€77.00
Price is excluding VAT and does not include packaging neither shipping

A potent activator of Nrf2-regulated activity, both in vitro (10 μM) and in mice (50 mg/kg)
Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or...

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Territorial Availability: Available through Bertin Technologies only in Europe
Product Overview:
A potent activator of Nrf2-regulated activity, both in vitro (10 μM) and in mice (50 mg/kg)
Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both in vitro and in mice. Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1. Furthermore, treatment of mice mice with 50 mg/kg 2-trifluoromethyl-2’-methoxychalcone leads to a 4.5- and 4.6-fold increase in the expression of GCLM and NQO1, respectively, in the small intestine compared to controls.
Size: 5 mg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 365 days maximum after production
CAS Number: 1309371-03-6
Molecular Formula: C17H13F3O2
SMILES: COC1=C(C(/C=C/C2=CC=CC=C2C(F)(F)F)=O)C=CC=C1
Molecular Weight: 306.3
Formulation: A solution in methyl acetate
Purity: ≥98%
Custom Code: 2932996560
UNSPSC code: 12352100
UN Number: UN1231

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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