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VU0361737

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    VU0361737
  • VU0361737
Cat No: 16295
Chemicals - Biochemicals
Cayman
€43.00
Price is excluding VAT and does not include packaging neither shipping

A selective PAM of mGluR4, displaying EC50 values of 110 and 240 nM for rat and human receptors, respectively; passes the blood-brain barrier to act centrally in rats
Metabotropic glutamate receptors (mGluRs) modulate brain excitability through diverse...

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Territorial Availability: Available through Bertin Technologies only in Europe
Product Overview:
A selective PAM of mGluR4, displaying EC50 values of 110 and 240 nM for rat and human receptors, respectively; passes the blood-brain barrier to act centrally in rats
Metabotropic glutamate receptors (mGluRs) modulate brain excitability through diverse mechanisms. VU0361737 is a selective positive allosteric modulator (PAM) of mGluR4, displaying EC50 values of 110 and 240 nM for rat and human receptors, respectively. It has weak or no activity at other mGluRs. VU0361737 passes the blood-brain barrier to act centrally in rats. VU0361737, alone or in combination with an mGluR2 selective PAM, does not potentiate glutamate responses through mGlu2/4 heterodimers.
Size: 1 mg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 730 days maximum after production
CAS Number: 1161205-04-4
Molecular Formula: C13H11ClN2O2
SMILES: O=C(C1=NC=CC=C1)NC2=CC=C(Cl)C(OC)=C2
Molecular Weight: 262.7
Formulation: A crystalline solid
Purity: ≥98%
Custom Code: 2908999502
UNSPSC code: 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : VU0361737 There are 9 products.