N-Carbamyl-L-Glutamic Acid

Biochemicals - Small Molecule Activators

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Cat No: 23512

Biochemicals - Small Molecule Activators

N-Carbamyl-L-glutamic acid is an activator of carbamoyl phosphate synthetase 1 (CPS1), the first enzyme in the urea cycle.{38610} It is a structural analog of N-acetyl-glutamate, an endogenous CPS1 activator. N-Carbamyl-L-glutamic acid (500 mg/kg) red...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(aminocarbonyl)-L-glutamic acid

Correlated keywords:

52093-31-9 Carbaglu Carbamylglutamic OE-312 OE312 Ureidoglutaric CPS-1 coenzyme A

Product Overview:
N-Carbamyl-L-glutamic acid is an activator of carbamoyl phosphate synthetase 1 (CPS1), the first enzyme in the urea cycle.{38610} It is a structural analog of N-acetyl-glutamate, an endogenous CPS1 activator. N-Carbamyl-L-glutamic acid (500 mg/kg) reduces 2-ketoisocaproate-induced hyperammonemia in a mouse model of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.{38609} It inhibits cell proliferation of a variety of cancer cell lines with IC50 values ranging from 5 to 7.5 nM.{38608} It also inhibits tumor growth by 80 and 82% in orthotopic mouse models of pancreatic and triple-negative breast cancer, respectively, when administered at a dose of 120 mg/kg per day for 10 days. Formulations containing N-carbamyl-L-glutamic acid have been used in the treatment of primary N-acetyl-glutamate synthase deficiency.

Size	1 g
Shipping	room temp.
CAS Number	1188-38-1
Molecular Formula	C₆H₁₀N₂O₅
SMILES	OC(CC[C@H](NC(N)=O)C(O)=O)=O
Molecular Weight	190,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2924.19
UNSPSC code	12352100

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MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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