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8-pCPT-2'-O-Me-Cyclic AMP (sodium salt)

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    8-pCPT-2'-O-Me-Cyclic AMP (sodium salt)
  • 8-pCPT-2'-O-Me-Cyclic AMP (sodium salt)
Cat No: 17143
Cayman
€115.00
Price is excluding VAT and does not include packaging neither shipping

An analog of cAMP that super-activates EPACs (AC50 = 1.8 µM), dissociating GDP from Rap1 more strongly than the natural EPAC agonist, cAMP; strongly selective for EPAC over PKA
Exchange proteins activated by cAMP (EPACs) are guanine nucleotide exchange...

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Territorial Availability: Available through Bertin Technologies only in Europe
Product Overview:
An analog of cAMP that super-activates EPACs (AC50 = 1.8 µM), dissociating GDP from Rap1 more strongly than the natural EPAC agonist, cAMP; strongly selective for EPAC over PKA
Exchange proteins activated by cAMP (EPACs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-pCPT-2'-O-Me-Cyclic AMP is an 8-(4-chlorophenylthio) analog of cAMP that activates EPACs (AC50 = 1.8 µM). It is a super-activator of EPACs in that it dissociates GDP from Rap1 more strongly than the natural EPAC agonist, cAMP. 8-pCPT-2'-O-Me-cAMP is strongly selective for EPAC over the cAMP-activated kinase PKA. It does not discriminate between EPAC1 and EPAC2 and is used extensively to elucidate the roles of these Rap GEFs in cell function.
Size: 500 µg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 730 days maximum after production
CAS Number: 634207-53-7
Molecular Formula: C17H16N5O6ClPS • Na
SMILES: O=P1([O-])O[C@H]2[C@@H](OC)[C@H](N3C(SC4=CC=C(Cl)C=C4)=NC5=C3N=CN=C5N)O[C@@H]2CO1.[Na+]
Molecular Weight: 507.8
Formulation: A crystalline solid
Purity: ≥98%
Custom Code: 2903990002
UNSPSC code: 12352100

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