A mycotoxin from F. moniliforme, a fungus of grains; at 1 μM, inhibits sphingosine N-acyltransferase; fumonisins, found as contaminants in foods, induce apoptosis via altered sphingolipid metabolism, resulting in hepatotoxicity and nephrotoxicity
Wang, E., Norred, W.P., Bacon, C.W., et al. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266 14486-14490 (1991).
Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al. Fumonisins -
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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