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Fumonisin B2

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    Fumonisin B<sub>2</sub>
  • Fumonisin B<sub>2</sub>
Cat No: 13227
Chemicals - Miscellaneous Chemicals
Cayman
€131.00
Price is excluding VAT and does not include packaging neither shipping

A mycotoxin from F. moniliforme, a fungus of grains; at 1 μM, inhibits sphingosine N-acyltransferase; fumonisins, found as contaminants in foods, induce apoptosis via altered sphingolipid metabolism, resulting in hepatotoxicity and nephrotoxicity
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Territorial Availability: Available through Bertin Technologies only in Europe
Product Overview:
A mycotoxin from F. moniliforme, a fungus of grains; at 1 μM, inhibits sphingosine N-acyltransferase; fumonisins, found as contaminants in foods, induce apoptosis via altered sphingolipid metabolism, resulting in hepatotoxicity and nephrotoxicity
Fumonisin B2 is a mycotoxin originally isolated from F. moniliforme, a prevalent fungus of corn and other grains. Fumonisins cause food poisoning in livestock and humans following the consumption of Fusarium-infested corn. Fumonisin B2, like fumonisin B1 (Item No. 62580), structurally resembles sphingosine and, at 1 μM, inhibits sphingosine N-acyltransferase (>90%) in hepatocytes. Fumonisins induce apoptosis via altered sphingolipid metabolism, resulting in hepatotoxicity and nephrotoxicity. It is now known that fumonisins are produced by fungi other than F. moniliforme and occur as contaminants in a wide variety of foods.
Size: 500 µg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 730 days maximum after production
CAS Number: 116355-84-1
Molecular Formula: C34H59NO14
SMILES: C[C@H](N)[C@@H](O)C[C@H](O)CCCCCC[C@H](C)C[C@H](OC(C[C@H](C(O)=O)CC(O)=O)=O)[C@H](OC(C[C@H](C(O)=O)CC(O)=O)=O)[C@H](C)CCCC
Molecular Weight: 705.8
Formulation: A crystalline solid
Purity: ≥95%
Custom Code: 2918992090
UNSPSC code: 12352100
UN Number: UN2811

Wang, E., Norred, W.P., Bacon, C.W., et al. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266 14486-14490 (1991).

Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al. Fumonisins - novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl Environ Microbiol 54 1806-1811 (1988).

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