Pheophorbide a

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Pheophorbide a

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Cat No: 16072

Biochemicals - Natural Products

Pheophorbide a is a product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer.{26143} It has been reported to inhibit U87MG cells with an IC50 value of 2.8 µg/ml and demonstrates cytos...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9-ethenyl-14-ethyl-21R-(methoxycarbonyl)-4S,8,13,18-tetramethyl-20-oxo-3S-phorbinepropanoic acid

Correlated keywords:

28979-?78-?4 29702-?69-?0 chlorophyll microalgae natural products photosensitizers photodynamic therapy cancers glioblastoma antiproliferation anti proliferation anti-proliferation melanoma breasts lungs selective activity breakdown therapies treatments glioblastoma cells growth in vitro a5 inhibits inhibitors inhibitions Phaeophorbide a antiproliferative

Product Overview:
Pheophorbide a is a product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer.{26143} It has been reported to inhibit U87MG cells with an IC50 value of 2.8 µg/ml and demonstrates cytostatic activity specifically against glioblastoma cells without affecting normal cells.{26144} It also displays antiproliferative activity against melanoma, breast, and lung cancer cells in vitro at 100 µg/ml.{26145}

Size	25 mg
Shipping	dry ice
CAS Number	15664-29-6
Molecular Formula	C₃₅H₃₆N₄O₅
SMILES	O=C1[C@H](C(OC)=O)C2=C3N/C(C(C)=C31)=C\C(C(CC)=C/4C)=NC4=C/C5=C(C=C)C(C)=C(/C=C6[C@@H](C)[C@H](CCC(O)=O)C2=N/6)N5
Molecular Weight	592,7
Formulation	A crystalline solid
Purity	≥90% (mixture of diastereomers)
Custom Code	2933.49
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.