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Nitrotyrosine BSA

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    Nitrotyrosine BSA
  • Nitrotyrosine BSA
Cat No: 89542
Chemicals - Api/drug/substrate/ Analytical Standard
Cayman
€165.00
Price is excluding VAT and does not include packaging neither shipping

Nitrotyrosine BSA is a positive control for detection of protein tyrosine nitration by WB using nitrotyrosine antibodies.
This product can be used as a positive control for immunoblotting experiments using Cayman Chemical’s Nitrotyrosine Polyclonal Ant...

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: 200 µg

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Product Overview:
Nitrotyrosine BSA is a positive control for detection of protein tyrosine nitration by WB using nitrotyrosine antibodies.
This product can be used as a positive control for immunoblotting experiments using Cayman Chemical’s Nitrotyrosine Polyclonal Antibody (Item No. 10189540) and Nitrotyrosine Monoclonal Antibody (Item No. 189542). Nitric oxide (NO) is a product of the enzymatic conversion of arginine to citrulline by nitric oxide synthase. NO reacts rapidly with superoxide (6.7 x 109 M−1sec−1) to form peroxynitrite. At physiological pH and in the presence of transition metals, peroxynitrite undergoes heterolytic cleavage to form hydroxyl anion and nitronium ion, the latter of which nitrates protein tyrosine residues. Thus, the presence of nitrotyrosine on proteins can be used as a marker for peroxynitrite formation in vivo. Nitrotyrosine has been shown to be present in proteins from a variety of clinical conditions including atherosclerotic lesions of human coronary arteries, postischemic heart, and placenta during preeclampsia. Increased nitration of proteins in motor neurons has been identified in patients with amyotrophic lateral sclerosis and may be due to mutations in superoxide dismutase.
Size: 200 µg
Shipping: dry ice
Stability: Store at -80 degrees; shelf life 730 days maximum after production
Application(s):

WB: 50-100 ng is recommended for use as a positive control

Formulation: 200 µg of nitrotyrosine BSA in 500 µl TBS, pH 7.4
Custom Code: 3822000002
UNSPSC code: 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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