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Sphingosine Kinase 1 (human recombinant)

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    Sphingosine Kinase 1 (human recombinant)
  • Sphingosine Kinase 1 (human recombinant)
Cat No: 10348
Proteins - Enzymes
Cayman
€416.00
Price is excluding VAT and does not include packaging neither shipping

Source: human recombinant N-terminal His-tagged protein from Sf9 cells • SPHK1 catalyzes the production of sphingosine-1-phosphate, a lipid mediator with broad spectrum of biological activities including cell proliferation, survival, migration, cytosk...

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: 25 µg

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
Product Overview:
Source: human recombinant N-terminal His-tagged protein from Sf9 cells • SPHK1 catalyzes the production of sphingosine-1-phosphate, a lipid mediator with broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.
Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date two isoforms of SPHK, SPHK1 and SPHK2, have been identified & characterized from mammalian cells. Among them, SPHK1 has been implicated to play a role in signaling pathways in mast cells and in TNF-α-triggered responses of fibroblasts and epithelial cells. Recent findings also indicate that SPHK1 mRNA levels are increased in a variety of human tumors. Brain tumors with high SPHK1 expression correlated with poor survival of patients and high expression of SPHK1 appears to be an oncogenic event required for erythroleukaemic progression. Thus SPHK is a potential therapeutic target for the control of cancer and inflammation.
Size: 25 µg
Shipping: dry ice
Stability: Store at -80 degrees; shelf life 365 days maximum after production
Formulation: 25 mM HEPES, pH 8.0, containing 150 mM sodium chloride, 3 mM DTT, 0.05% Polysorbate 20, and 25% glycerol
Purity: ≥80% estimated by SDS-PAGE
Custom Code: 3507907000
UNSPSC code: 12352204

Taha, T.A., Hannun, Y.A., and Obeid, L.M. Sphingosine kinase: Biochemical and cellular regulation and role in disease. J Biochem Mol Biol 39(2) 113-131 (2006).

Leclercq, T.M., and Pitson, S.M. Cellular signalling by sphingosine kinase and sphingosine 1-

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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