Human Therapeutic IgG2 ELISA Kit

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Cat No: 500960

Assay Kits - Elisa

Human therapeutic antibodies have become increasingly common components of early drug discovery and development portfolios in the pharmaceutical and biotech industries. As part of preclinical toxicology assessment of these agents, they are routinely t...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

ELISA drug discovery cytotoxicity toxicology non-human primates rhesus cynomolgus monkeys pharmacokinetics serum endogenous homology immunoglobulins species EIAs enzymes immunoassays kits measures measurements humans antibody antibodies IgG1 effectors Fc receptors leukocytes mediates antibody-induced cellular cells ADCC complement-mediated complements rodent plasma

Product Overview:
Human therapeutic antibodies have become increasingly common components of early drug discovery and development portfolios in the pharmaceutical and biotech industries. As part of preclinical toxicology assessment of these agents, they are routinely tested in non-human primates, primarily in rhesus or cynomolgus monkeys. In order to assess the pharmacokinetics of the human antibodies in monkey serum, it is necessary to have an assay that is capable of distinguishing the experimentally-introduced human IgG from the endogenous monkey IgG. Cayman’s Human Therapeutic IgG2 ELISA Kit is an immunometric assay which can be used to measure human IgG2 in monkey or rodent plasma and serum without prior sample purification. The standard curve spans the range of 3.13-200 ng/ml, with an LLOQ of 3.13 ng/ml. The assay has been validated in sera from rats and cynomolgus monkeys.

Size	96 wells
Shipping	wet ice
Custom Code	3822.19
UNSPSC code	41116104

Chan, A.C., and Carter, P.J. Therapeutic antibodies for autoimmunity and inflammation. Nat Rev Immunol 10 301-16 (2010).

Salfeld, J.G. Isotype selection in antibody engineering. Nat Biotech 25 1369-1372 (2007).

Stubenrauch, K., Wessels, U., and Lenz, H. E

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.