(±)9(10)-DiHOME

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(±)9(10)-DiHOME

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Cat No: 53400

Biochemicals - Lipids

(±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME (Item No. 52400), a cytochrome P450-derived epoxide of linoleic acid (Item Nos. 90150
90150.1
21909) also known as leukotoxin.{8529} It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(±)9,10-dihydroxy-12Z-octadecenoic acid

Correlated keywords:

CYP450 Dihydroxy-Octadec-12-Enoic Acid Sf 21 lac Z

Product Overview:
(±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME (Item No. 52400), a cytochrome P450-derived epoxide of linoleic acid (Item Nos. 90150
90150.1
21909) also known as leukotoxin.{8529} It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils.{17057} It is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike leukotoxin, which is only toxic to cells containing sEH.{8529,17057} A mixture of 9(10)- and 12(13)-DiHOME induces cell death in rabbit renal proximal tubule cells concomitant with mitochondrial respiration dysfunction and induces lung injury, respiratory distress, and mortality in mice.{15651,5617} 9(10)-DiHOME is a toxic lipid mediator involved in acute respiratory distress syndrome (ARDS), a common and often fatal complication in severe burn victims.{17057,15651} Levels of 9(10)-DiHOME are increased in bronchoalveolar lavage fluid (BALF) from women, but not men, with chronic obstructive pulmonary disease (COPD).{42554} BALF levels are also increased in patients with allergic asthma following allergen exposure compared to patients without allergic asthma.{49189} It has been used as a plasma biomarker for sEH activity in vivo.{42555}

Size	25 µg
Shipping	dry ice
CAS Number	263399-34-4
Molecular Formula	C₁₈H₃₄O₄
SMILES	O[C@H](C/C=C\CCCCC)[C@H](O)CCCCCCCC(O)=O
Molecular Weight	314,5
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2918.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.