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α,β-Methyleneadenosine 5'-triphosphate (sodium salt)

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    α,β-<wbr/>Methyleneadenosine 5'-triphosphate (sodium salt)
  • α,β-<wbr/>Methyleneadenosine 5'-triphosphate (sodium salt)
Cat No: 10008956
Cayman
€59.00
Price is excluding VAT and does not include packaging neither shipping

A phosphonic analog of ATP and agonist of P2X1 and P2X3 (EC50 = ~1 µM); ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors; used as a stable analog of ATP to study the interaction of ATP with kinases and other proteins
α,β-Methylenea...

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Territorial Availability: Available through Bertin Technologies only in Europe
Product Overview:
A phosphonic analog of ATP and agonist of P2X1 and P2X3 (EC50 = ~1 µM); ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors; used as a stable analog of ATP to study the interaction of ATP with kinases and other proteins
α,β-Methyleneadenosine 5'-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 µM) and is ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors. Persistent activation of purinoceptors results in desensitization, resulting in an antagonist-like effect of αβ-methylene ATP. αβ-methylene ATP is used as a stable analog of ATP (Item No. 14498) to study the interaction of ATP with kinases and other proteins. It weakly binds and inhibits adenylate cyclase in a calcium-dependent manner (Ki= ~0.5 mM).
Size: 1 mg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 730 days maximum after production
CAS Number: 1343364-54-4
Molecular Formula: C11H15N5O12P3 • 3Na
SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(CP(OP(O)([O-])=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+]
Molecular Weight: 571.2
Formulation: A crystalline solid
Purity: ≥95%
Custom Code: 2835310000
UNSPSC code: 12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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