Thioredoxin 1 Truncated (human)

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Thioredoxin 1 Truncated (human) Monoclonal Antibody (Clone 7D11)

Cat No: 11543

Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to th...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Trx1 80 Trx80 thioldisulfide anti oxidant U 937 CD 4+ proinflammatory 7 D 11

Product Overview:
Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57137,57136} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} Trx1 can be truncated to form Trx80 or Trx84, which contain 80 or 84 amino acids from the N-terminus of full-length Trx1, respectively.{58380,58379} Full-length Trx1 contains a KKGQK amino acid sequence between positions 79 and 84, and cleavage at the KK motif leads to the generation of Trx80, whereas cleavage at lysine 84 generates Trx84.{58379} Trx80 is secreted from a variety of cell types, including U937 monocytes, cytotrophoblasts, and CD4+ T cells, and has been found in human plasma.{54301} Unlike full-length Trx1, Trx80 is catalytically inactive and has pro-inflammatory, rather than anti-inflammatory, activity.{54300} Cayman's Thioredoxin 1 Truncated (human) Monoclonal Antibody (Clone 7D11) can be used for direct ELISA, sandwich ELISA, flow cytometry (FC), immunofluorescence (IF), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes Trx80 and Trx84, but not full-length Trx1, by ELISA. However, under denaturing conditions of SDS-PAGE, the antibody recognizes Trx80 and Trx84 at approximately 9 to 10 kDa but also detects full-length Trx1 at approximately 12 kDa.

Size	1 ea
Shipping	wet ice
Host	Mouse
Antigen	N-terminal 80 amino acids of human Trx1
Clone	7D11
Isotype	IgG1
Application(s)	ELISA, IF, IP, WB
Formulation	100 µg of purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.